apalutamide will lower the level or effect of ethinylestradiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medication that are CYP3A4 substrates may end up in decrease exposure to these medications.Use of this site has actually been d